PMAPscore: Identify Prognosis-Related Pathways Altered by Somatic Mutation

We innovatively defined a pathway mutation accumulate perturbation score (PMAPscore) to reflect the position and the cumulative effect of the genetic mutations at the pathway level. Based on the PMAPscore of pathways, identified prognosis-related pathways altered by somatic mutation and predict immunotherapy efficacy by constructing a multiple-pathway-based risk model (Tarca, Adi Laurentiu et al (2008) <doi:10.1093/bioinformatics/btn577>).

Version:	0.1.1
Depends:	R (≥ 4.1.0)
Imports:	base, clusterProfiler, glmnet, graphics, grDevices, maftools, org.Hs.eg.db, pROC, stats, survival, survminer, utils
Suggests:	knitr, rmarkdown
Published:	2022-04-12
Author:	Junwei Han [aut, cre, cph], Yalan He [aut], Xiangmei Li [aut]
Maintainer:	Junwei Han <hanjunwei1981 at 163.com>
License:	GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation:	no
CRAN checks:	PMAPscore results

Documentation:

Reference manual:	PMAPscore.pdf
Vignettes:	PMAPscore

Downloads:

Package source:	PMAPscore_0.1.1.tar.gz
Windows binaries:	r-devel: PMAPscore_0.1.1.zip, r-release: PMAPscore_0.1.1.zip, r-oldrel: PMAPscore_0.1.1.zip
macOS binaries:	r-release (arm64): PMAPscore_0.1.1.tgz, r-oldrel (arm64): PMAPscore_0.1.1.tgz, r-release (x86_64): PMAPscore_0.1.1.tgz, r-oldrel (x86_64): PMAPscore_0.1.1.tgz
Old sources:	PMAPscore archive

Linking:

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