integIRTy: Integrating Multiple Modalities of High Throughput Assays Using
Item Response Theory
Provides a systematic framework for
integrating multiple modalities of assays profiled on the same set of
samples. The goal is to identify genes that are altered in cancer
either marginally or consistently across different assays. The
heterogeneity among different platforms and different samples are
automatically adjusted so that the overall alteration magnitude can
be accurately inferred. See Tong and Coombes (2012)
<doi:10.1093/bioinformatics/bts561>.
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