scDiffCom infers cell type to cell type communication signals from scRNA-seq Seurat objects, and more particularly investigates how these interactions change between two biological conditions. The package relies on a internal collection of ligand-receptor interactions (available for human and mouse) retrieved from seven public and curated databases.
Display LRI databases
# Install release version from CRAN
install.packages("scDiffCom")
# Install development version from GitHub
devtools::install_github("CyrilLagger/scDiffCom")As an introduction, please look at the documentation and this vignette.
For a concrete and large-scale project that used scDiffCom, please look at scagecom.org, our murine atlas of age-related changes in intercellular communication.
Please consider reading and citing our preprint here.