DRviaSPCN: Drug Repurposing in Cancer via a Subpathway Crosstalk Network
A systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results.
| Version: |
0.1.2 |
| Depends: |
R (≥ 3.6) |
| Imports: |
ChemmineR, GSVA, clusterProfiler, graphics, igraph, pheatmap, rvest, xml2, stats |
| Suggests: |
rmarkdown, knitr, DT |
| Published: |
2022-03-03 |
| Author: |
Junwei Han [aut, cre, cph],
Jiashuo Wu [aut] |
| Maintainer: |
Junwei Han <hanjunwei1981 at 163.com> |
| License: |
GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| NeedsCompilation: |
no |
| CRAN checks: |
DRviaSPCN results |
Documentation:
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